The pain sensation occurs when the neural pathways are stimulated by stimuli originating from a tissue disorder in the spinal cord, where information on nonsensical pain is primarily processed. From there, the information is transferred to the brain, where it finally creates the sense of pain. In this way, most researchers believe that we are aware of the pain.
In November 2016, Science published an interesting study by the Division of Neurophysiology at MedUni, Vienna’s Center for Brain Research, in which they discovered that pain is not only a matter of nerve cells but also of non-neural cells, the glial cells Are involved in clinical pain models and their activation is likely to cause pain.